State of the art medicinal chemistry and molecular design capabilities to e.g. optimize novel small molecules to identify high quality drug candidates.
Facilities to explore the molecular interactions and biophysics to investigate protein/ligand interactions that are critical to the design of the next generation of pharmaceutical agents. Applied techniques are e.g. x-ray crystallography, surface plasmon resonance (SPR) imaging, isothermal calorimetry (ITC), and computational design.
In vitro pharmacology labs to develop and use molecular and cellular pharmacology assays to generate data on compound potencies, efficacies and specificities across all stages from hit identification to the definition of a clinical development candidate. Special focus is also on High Content Screening (HCS) and Phenotypic Drug Discovery e.g. in the combination with high-resolution microscopy with high-throughput drug screening capabilities. Other activities are 2D- and 3-dimensional (spheroid) cell culture models and profiling of decisive cellular parameters.
Facilities for the discovery of monoclonal antibodies, therapeutic proteins and antibody drug conjugates. Profound protein engineering know how, expression and purification techniques including in vitro compound characterization by state of the art technologies. Strong protein and cell sciences know how for the generation of manufacturing cell lines & scalable processes.